Publications by authors named "P Bharate"
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View Article and Find Full Text PDFImaging of biomolecules guides our understanding of their diverse structures and functions. Real-space imaging at sub-nanometre resolution using cryo-electron microscopy has provided key insights into proteins and their assemblies. Direct molecular imaging of glycans-the predominant biopolymers on Earth, with a plethora of structural and biological functions-has not been possible so far.
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- Cell surfaces have glycoconjugates, playing a key role in cellular communication; mannose is a vital component often found on pathogens.
- Janus glycodendrimers, which mimic glycolipids, can self-assemble into glycodendrimersomes that resemble cell surfaces, but creating more complex versions has been a challenge.
- Recent research demonstrated that a new "click" reaction can combine oligosaccharides with Janus glycodendrimers, resulting in nanoscale glycodendrimersomes that show increased biological activity due to their unique structural features.*
Automated glycan assembly of arabinomannan oligosaccharides from .
Beilstein J Org Chem
December 2019
Article Synopsis
- Arabinomannan (AM) polysaccharides serve as important clinical biomarkers for Mycobacterium tuberculosis (MTB) infections, affecting how host cells respond and how macrophages are activated.
- Understanding these AM oligosaccharides is crucial for creating new diagnostic tools and therapeutic agents for tuberculosis.
- The study utilized automated glycan assembly (AGA) to efficiently synthesize various AM oligosaccharides with specific linkages, improving the synthesis process through a capping step and optimized reaction conditions.
Multivalent mannose-functionalized nanoparticles self-assembled from amphiphilic β-cyclodextrins (β-CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin (DOX)-loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor-mediated endocytosis by MDA-MB-231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis.
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