Publications by authors named "P Beurrier"
Article Synopsis
- Factor XI deficiency is a rare bleeding disorder, and it's hard to predict how much a person will bleed based on their Factor XI levels.
- A study looked at pregnant women with low Factor XI levels to see how they were managed during childbirth and their experiences with pain relief methods like epidurals and spinals.
- The results showed that a lot of women had successful pain relief procedures without complications, and it was suggested that it's safe to use these methods if Factor XI levels are above 30 IU/dL.
Background: Desmopressin (DDAVP) is used in patients with moderate/mild hemophilia A (PWMHs) to increase their factor VIII (FVIII) level and, if possible, normalize it. However, its effectiveness varies between individuals. The GIDEMHA study aims to investigate the influence of gene variants.
View Article and Find Full Text PDFArticle Synopsis
- Von Willebrand disease (VWD) is the most common inherited bleeding disorder, but data on how patients are treated during hospitalizations is limited.
- A study named Hopscotch-WILL looked at 988 VWD patients over four years to understand their treatment and factors driving the use of coagulation factors during hospital stays.
- Results showed that 15% of patients were hospitalized needing von Willebrand factor treatment, with low levels of VWF and FVIII being significant, and usage varied based on VWD type and the reason for hospitalization.
Article Synopsis
- Turoctocog alfa, a Factor VIII replacement therapy, was evaluated for its effectiveness in patients with hemophilia A undergoing surgery, using data from a national database.
- The study analyzed 86 surgeries (49 major and 37 minor) across 56 patients, revealing a high overall clinical efficacy of 89.5%, with minimal complications.
- Results showed that patients with mild hemophilia required fewer infusions and lower doses than those with severe hemophilia, and no significant adverse events or complications occurred during the procedures.
Introduction: Dominant-negative effects have been described for 10 F11 variants in the literature.
Aim: The current study aimed at identifying putative dominant-negative F11 variants.
Material And Methods: This research consisted in a retrospective analysis of routine laboratory data.