Publications by authors named "P Bercik"
Article Synopsis
- Recent research is exploring how the gut microbiome (GMB) may influence schizophrenia (SCZ), including its development, symptoms, and treatment responses.
- Studies indicate that the GMB composition in animal models of SCZ differs from control groups and correlates with SCZ-like behaviors.
- Fecal microbiota transplantation (FMT) from SCZ patients to rodents has shown altered brain functions and behaviors similar to those seen in SCZ, suggesting these models may help deepen our understanding of the disorder, though further validation is needed.
Article Synopsis
- Imbalances in proteolytic activity are linked to inflammatory bowel diseases (IBD), where intestinal proteases can disrupt homeostasis and promote inflammation through protease-activated receptors (PARs).
- This study focuses on the role of microbial proteases in activating PAR2 and found that proteolytic cleavage of PAR2 increases intestinal permeability and inflammation during colitis.
- Mice with a mutated, protease-resistant version of PAR2 showed less severe colitis, suggesting that targeting PAR2 cleavage by bacterial proteases could be a potential therapeutic approach for IBD.
Background & Aims: Intestinal epithelial cell (IEC) damage is a hallmark of celiac disease (CeD); however, its role in gluten-dependent T-cell activation is unknown. We investigated IEC-gluten-T-cell interactions in organoid monolayers expressing human major histocompatibility complex class II (HLA-DQ2.5), which facilitates gluten antigen recognition by CD4 T cells in CeD.
View Article and Find Full Text PDFOur recent randomized, placebo-controlled study in Irritable Bowel Syndrome (IBS) patients with diarrhea or alternating bowel habits showed that the probiotic (BL) NCC3001 improves depression scores and decreases brain emotional reactivity. However, the involved metabolic pathways remain unclear. This analysis aimed to investigate the biochemical pathways underlying the beneficial effects of BL NCC3001 using metabolomic profiling.
View Article and Find Full Text PDFUp to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provide additional antibiotic treatment or to adopt a conservative symptom-based approach. Here, we review the literature on CDI-related PI-IBS and compare the findings with PI-IBS.
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