Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta.

DNA polymerase beta (Pol beta) is an error-prone enzyme whose up-regulation has been shown to be a genetic instability enhancer as well as a contributor to cisplatin resistance in tumor cells. In this work, we describe the isolation of new Pol beta inhibitors after high throughput screening of 8448 semipurified natural extracts. In vitro, the selected molecules affect specifically Pol beta-mediated DNA synthesis compared with replicative extracts from cell nuclei.

[Obstructive sleep apnea syndrome in adults and cardiovascular risk].

Sleep obstructive apnea syndrome (SOAS) is a common condition with a strong male predominance. Its incidence is more than 1 percent in the population as a whole. It exists in snorers.

[Conduction disorders in Cheyne-Stokes respiration caused by cardiac insufficiency].

This report describes a case of Cheyne-Stokes respiration linked to heart failure, with periodic disturbances of atrioventricular conduction during the augmentation phase of the tidal volume. The circulatory retardation caused by heart failure induced a phase lag of the negative retroaction system and secondarily an oscillation in the respiratory command. The conduction disturbances resulted from vagal stimulation of multifactorial origin.

[Rapid development of mitral and aortic stenoses with chronic hemodialysis. A report of 2 cases].

Chronic renal failure is associated with a high incidence of calcifications of the mitral anulus, which if severe enough may result in mitral stenosis or regurgitation. Aortic valve calcifications, though less frequent, may also occur and cause aortic valve stenosis, as observed in two patients. In hemodialysed patients, identification of valvular aortic stenosis might be difficult on a clinical basis since the systolic ejection murmur might be attributed to aortic sclerosis or a high output state and left ventricular hypertrophy to previous hypertensive disease.