Publications by authors named "P Bawa"
Article Synopsis
- - The study focuses on creating mature thyroid follicular cells (TFCs) from human induced pluripotent stem cells (iPSCs) to address hypothyroidism, whether from surgeries or congenital issues.
- - Researchers developed a new iPSC line that helps identify TFCs and optimized a serum-free media process where factors like BMP4 and FGF2 are crucial for guiding cell differentiation into TFCs.
- - Although the resulting TFCs showed proper development and function in lab tests, they were ineffective in treating hypothyroidism when transplanted into mice with the condition.
Article Synopsis
- * Detailed protocols are provided for preparing and expanding airway basal stem cells from mice and induced pluripotent stem cells, followed by methods for their transplantation into mice.
- * Successful engraftment leads to the restoration of key airway functions and cell types, with timelines for generating and using these stem cells outlined for researchers.
Macrophages are critical for maintenance and repair of mucosal tissues. While functionally distinct subtypes of macrophage are known to have important roles in injury response and repair in the lungs, little is known about macrophages in the proximal conducting airways. Single-cell RNA sequencing and flow cytometry demonstrated murine tracheal macrophages are largely monocyte-derived and are phenotypically distinct from lung macrophages at homeostasis.
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