Haploidentical, G-CSF-primed, unmanipulated bone marrow transplantation for patients with high-risk hematological malignancies: an update.

Ninety-seven patients affected by high-risk hematological malignancies underwent G-CSF primed, unmanipulated bone marrow (BM) transplantation from a related, haploidentical donor. All patients were prepared with an identical conditioning regimen including Thiotepa, Busilvex, Fludarabine (TBF) and antithymocyte globulin given at myeloablative (MAC = 68) or reduced (reduced intensity conditioning (RIC) = 29) dose intensity and received the same GvHD prophylaxis consisting of the combination of methotrexate, cyclosporine, mycofenolate-mofetil and basiliximab. Patients were transplanted in 1st or 2nd CR (early phase: n = 60) or in > 2nd CR or active disease (advanced phase: n = 37).

Allogeneic hematopoietic cell transplantation from unrelated donors in multiple myeloma: study from the Italian Bone Marrow Donor Registry.

To evaluate trends in allografting from unrelated donors, we conducted a study on 196 consecutive myeloma patients transplanted between 2000 and 2009 in Italy. Twenty-eight percent, 37%, and 35%, respectively, received myeloablative, reduced-intensity, and nonmyeloablative conditioning. In these 3 cohorts, 1-year and 5-year transplantation-related mortalities were 28.

Haploidentical, unmanipulated, G-CSF-primed bone marrow transplantation for patients with high-risk hematologic malignancies.

Unlabelled: Eighty patients with high-risk hematologic malignancies underwent unmanipulated, G-CSF–primed BM transplantation from an haploidentical family donor. Patients were transplanted in first or second complete remission (CR, standard-risk: n =45) or in > second CR or active disease (high-risk: n =35). The same regimen for GVHD prophylaxis was used in all cases.

[Exposure to air pollutants in the polyclinic of Bari].

This work pertains to the study of exposure to air pollution and noise, of any citizen, in any time of day, within the perimeter of the Polyclinic of Bari. We utilized "dynamic" samplings, in a period of 24 hours, along a walking trail that lasted about 70 minutes, divided on the roads inside the general hospital, performed by voluntary people carrying, by shoulder, a bag containing necessary tools, with their sample heads placed externally in the respiratory area. The values of the environmental survey revealed, particularly, the presence of atmospheric concentrations of PM10 of 63,4 microg/m3 as average value of the whole day and 93 microg/m3 as maximum average value in one hour, far above the limits expected by law for the protection of human health (maximum average value of 50 pg/m3 in 24 hours), almost the whole day and in all areas interested in this study.

[Temporary hearing threshold shift in policemen after firearm training].

Background: The paper involves exposure to noise of the State Police officers connected with the use of firearms. The noise generated by these weapons is of short duration and high intensity.

Methods: The research was carried out during the sessions of firearm training of State Police officers to assess exposure to noise.