Publications by authors named "P Bataille"
Endotypes are characterized by the immunological, inflammatory, metabolic, and remodelling pathways that explain the mechanisms underlying the clinical presentation (phenotype) of a disease. Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease caused by COL7A1 pathogenic variants. Although underscored by animal studies, the endotypes of human RDEB are poorly understood.
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- Breaking bad news is a challenging communication task in medicine, prompting a study on the effectiveness of an active learning course for fifth-year students.
- Students were split into two groups: one received hands-on training with multidisciplinary discussions and video workshops, while the other only attended traditional classes.
- Results showed that the actively trained group scored significantly higher in communication skills during practical exams, indicating the training's effectiveness, but further research is needed for long-term validation.
Article Synopsis
- Epidermal necrolysis (EN) includes severe conditions like Stevens-Johnson syndrome and is primarily drug-induced, with notable differences in incidence and outcomes between children and adults.
- A study analyzed data from the French Health System to compare EN cases in both demographics, examining incidence, suspected drug exposure, and mortality rates.
- Results showed that EN is less common in children (1.5 cases/million) compared to adults (2.6 cases/million), with children having a lower rate of drug exposure before onset and significantly lower mortality (1.4% vs. 19.4%).
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions mainly triggered by drugs, with limited research on their occurrence in children.
- A study analyzed pediatric cases of SJS-TEN from the WHO VigiBase database to identify drugs associated with these reactions, covering data from 1967 to 2022.
- The research found significant signals for 165 drugs, predominantly antiepileptics and anti-infectious medications, with lamotrigine and carbamazepine being the most notable, while it ruled out vaccines as a significant risk factor.