Publications by authors named "P Bastos"
Background: Spinocerebellar ataxia 27B is the most common genetic late onset cerebellar ataxia (LOCA). However, it commonly overlaps with other genetic LOCA as with the cerebellar form of multiple system atrophy (MSA-C).
Objectives: To pinpoint which clinical signs and symptoms best discriminate between FGF14 + from FGF14 - patients at symptoms' onset.
We introduce a phylogeny-aware framework for predicting linear B-cell epitope (LBCE)-containing regions within proteins. Our approach leverages evolutionary information by using a taxonomic scaffold to build models trained on hierarchically structured data. The resulting models present performance equivalent or superior to generalist methods, despite using simpler features and a fraction of the data volume required by current state-of-the-art predictors.
View Article and Find Full Text PDFPancreatic neuroendocrine tumors (panNETs) are a group of neoplasms with heterogenous biological and clinical phenotypes. Although historically regarded as rare, the incidence of these tumors has been increasing, mostly owing to improvements in the detection of small, asymptomatic tumors with imaging. The heterogeneity of these lesions creates significant challenges regarding diagnosis, staging, and treatment.
View Article and Find Full Text PDFArticle Synopsis
- Non-fermenting Gram-negative bacilli (NFGNB) other than Pseudomonas and Acinetobacter are significant pathogens that cause healthcare-associated infections and show complex drug resistance, yet their characteristics remain underexplored.
- A study from January 2020 to December 2023 examined hospitalized patients with positive blood cultures for less common NFGNB, identifying key clinical features and factors linked to patient mortality.
- Results showed Stenotrophomonas maltophilia and Achromobacter species as the most common pathogens, with bloodstream infections mostly originating from intravascular devices and respiratory tract; factors like older age and chronic conditions significantly increased in-hospital mortality rates.
Article Synopsis
- The study aimed to analyze how well biologic drugs (IL-23 and IL-17 inhibitors) work for treating psoriasis in patients aged 65 and older compared to younger patients.
- It found that elderly patients had a higher risk of discontinuing treatment, especially with IL-23 inhibitors, while IL-17 inhibitors didn't show a significant difference.
- Additionally, factors like previous treatments influenced the likelihood of continuing or stopping the medication in elderly patients.