Publications by authors named "P Bartsch"
Biofilm formation shields Staphylococcus epidermidis from host defense mechanisms, contributing to chronic implant infections. Using wild-type S. epidermidis 1457, a PIA-negative mutant (1457-M10), and an eDNA-negative mutant (1457ΔatlE), this study examined the influence of biofilm matrix components on human monocyte-derived macrophage (hMDM) interactions.
View Article and Find Full Text PDFInherently limited by poor bioavailability, antiviral agent tenofovir (TFV) is administered to people living with HIV in prodrug form. However, current prodrugs are prematurely metabolized, compromising access to HIV-infected cells and inducing toxicity. Inspired by lipid conjugate TFV exalidex (TXL), we recently disclosed TXL analogs with potent activity and robust hepatic stability in vitro, as well as attractive oral PK profiles in vivo.
View Article and Find Full Text PDFArticle Synopsis
- Orofacial clefts are the most common birth defects affecting the face, and improper healing after cleft palate surgery can result in oronasal fistulas (ONFs), which are troublesome connections between the mouth and nose.
- Current treatments using human tissue grafts for ONF repair are effective but carry risks like infection and rejection, leading to the need for further surgery.
- A new approach using an FDA-approved drug, FTY720, aims to improve healing by modifying immune responses and has shown promising results in laboratory mice, indicating potential for better treatment options in children with cleft palate issues.
Background: The aim of this study was to assess health-related quality of life (HRQOL) before and after treatment for intracerebral low-grade glioma.
Methods: Patients with low-grade glioma who underwent surgical tumor removal between 2012 and 2018 were eligible for this study. All individuals and their closest relatives received thorough preoperative (