Publications by authors named "P Bagchi"
Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), which are the only members of the gamma(γ) herpesviruses, are oncogenic viruses that significantly contribute to the development of various human cancers, such as Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's lymphoma, Kaposi's sarcoma, and primary effusion lymphoma. Oncogenesis triggered by γ-herpesviruses involves complex interactions between viral genetics, host cellular mechanisms, and immune evasion strategies. At the genetic level, crucial viral oncogenes participate in the disruption of cell signaling, leading to uncontrolled proliferation and inhibition of apoptosis.
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- The research highlights the economic importance of predicting potato late blight infections to lower production costs and reduce chemical use, which can harm human health.
- The study focuses on classifying late blight infections in potatoes across Europe using historical data from 1980 to 2000.
- By employing hybrid machine learning models and a combination of stacking classifiers and logistic regression, the researchers achieved a prediction accuracy of 87.22%, suggesting that further improvements could enhance the prediction and management of potato health.
TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ~60% of the mitochondrial proteome. In this study, we characterized a disease-causing mutation in human fibroblasts and noted significant decreases in TIM23 core protein levels (TIMM50, TIMM17A/B, and TIMM23). Strikingly, TIMM50 deficiency had no impact on the steady-state levels of most of its putative substrates, suggesting that even low levels of a functional TIM23 complex are sufficient to maintain the majority of TIM23 complex-dependent mitochondrial proteome.
View Article and Find Full Text PDFPurpose: To present a first principle-based, high-fidelity computational model for predicting full three-dimensional (3D) and time-resolved retinal microvascular hemodynamics taking into consideration the flow and deformation of individual blood cells.
Methods: The computational model is a 3D fluid-structure interaction model based on combined finite volume/finite element/immersed-boundary methods. Three in silico microvascular networks are built from high-resolution in vivo motion contrast images of the superficial capillary plexus in the parafoveal region of the human retina.
Article Synopsis
- Congenital heart defects can cause right ventricular (RV) pressure overload, leading to heart failure, prompting research into cell-based therapies like mesenchymal stromal cells (MSCs) and c-kit positive cells (CPCs) for restoring function.
- In a study, juvenile rats underwent pulmonary artery banding to induce RV pressure overload, followed by the injection of different cell types, with results analyzed using advanced protein profiling techniques.
- The findings showed that MSC therapy significantly reversed changes in RV proteins caused by pressure overload, outperforming other cell types, indicating the potential effectiveness of these therapies in cardiac recovery.