Publications by authors named "P BOURGOIN"
Article Synopsis
- This study aimed to explore the link between the minimum lymphocyte count (Ly_Min) after cardiac surgery with cardiopulmonary bypass and the risk of infections within the first 30 days post-surgery.
- Researchers analyzed data from 1,428 pediatric cardiac surgeries and found that 8% of patients developed infections, with a significant correlation between lower Ly_Min and increased infection risk.
- The findings suggest that a Ly_Min below 1.105 x 10^9/L in the first postoperative day is a strong predictor of infections, highlighting the importance of monitoring lymphocyte levels in pediatric patients after surgery.
Article Synopsis
- Sickle cell disease (SCD) affects many people worldwide, and a serious issue related to it is called acute chest syndrome (ACS), which can make patients really sick and require hospitalization.
- Researchers studied data from 1998 to 2022 about young people with SCD who needed a special treatment called ECMO to help their lungs.
- They found that 55.8% of patients survived ECMO treatment, but there were complications, and not all patients, especially young kids and some adults, survived when ECMO was used for heart resuscitation.
A Streamlined Strategy for Basophil Activation Testing in a Multicenter Phase III Clinical Trial.
J Allergy Clin Immunol Pract
December 2024
Background: The basophil activation test (BAT) has been limited to research settings owing to technical issues. Novel approaches using dry, ready-to-use reagents and streamlined protocols offer greater flexibility and may open opportunities for easier implementation in clinical research.
Objective: Using a streamlined basophil activation test (sBAT) strategy and the settings of the baseline study of the Epicutaneous Immunotherapy in Toddlers with Peanut Allergy (EPITOPE) trial of EPicutaneous ImmunoTherapy, we aimed to assess the feasibility of implementing BAT in a multicenter trial and to evaluate its utility in predicting the outcomes of peanut double-blind placebo-controlled food challenge (DBPCFC).
Article Synopsis
- Microsatellite instability (MSI), often linked to mismatch repair deficiency in colorectal cancer (CRC), leads to numerous noncoding DNA mutations, particularly affecting RNA splicing sites.
- This research shows that these noncoding mutations happen early in tumor development, even before the cancer cells become mutated in their coding regions, and are associated with altered splicing patterns in mRNA.
- The altered RNA splicing impacts cellular differentiation and promotes the initiation of MSI CRC, indicating that these noncoding changes are significant for cancer progression before traditional coding mutations occur.
Pain perception and its modulation are fundamental to human learning and adaptive behavior. This study investigated the hypothesis that pain perception is tied to pain's learning function. Thirty-one participants performed a threat conditioning task where certain cues were associated with a possibility of receiving a painful electric shock.
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