Publications by authors named "P BARRAL"
Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identifying and expanding this patient population remains a pressing clinical need. Here, we report that an interferon-high immunophenotype locally enriched in cytotoxic lymphocytes and antigen-presenting macrophages is required for response.
View Article and Find Full Text PDFIntestinal homeostasis is maintained through the combined functions of epithelial and immune cells that collaborate to preserve the integrity of the intestinal barrier. However, the mechanisms by which immune cell populations regulate intestinal epithelial cell (IEC) homeostasis remain unclear. Here, we use a multi-omics approach to study the immune-epithelial crosstalk and identify CD1d-restricted natural killer T (NKT) cells as key regulators of IEC biology.
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- This study investigates the effectiveness of uterine artery embolization (UAE) with gelatin foam to manage delayed bleeding caused by vascularized retained products of conception (vRPOC) after abortion or miscarriage during a 5-year period at 11 French hospitals.
- Out of 224 patients evaluated, 94.2% experienced clinical success, although 7.3% showed persistent vRPOC at imaging follow-ups, with some minor and major complications reported.
- The results suggest that while UAE with gelatin foam is generally safe and effective, certain factors like having a hypertrophic uterine artery and using gelatin foam torpedoes may increase the risk of persistent bleeding issues.
Hypercontractile phenotype (HP) of the left ventricle (LV) is an actionable therapeutic target in patients with chronic coronary syndromes (CCS) or heart failure (HF), but its clinical recognition remains difficult. To assess the clinical variables associated with the HP. In a prospective, observational, multicenter study, we recruited 5122 patients (age 65 ± 11 years, 2974 males, 58%) with CCS and/or HF with preserved ejection fraction (EF).
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