Elevations of Cardiac Troponin in Patients Receiving Immune Checkpoint Inhibitors: Data From a Prospective Study.

Background: Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of cancer. However, immune-related adverse events are prevalent in patients receiving ICI therapy. A serious immune-related adverse event is ICI-myocarditis, which is complex to diagnose given that the significance of early symptoms and biomarker trajectories, such as high-sensitivity troponin T (hs-TnT) are unclear.

Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris.

Candida auris is a growing concern due to its resistance to antifungal drugs, particularly amphotericin B (AMB), detected in 30 to 60% of clinical isolates. However, the mechanisms of AMB resistance remain poorly understood. Here we investigated 441 in vitro- and in vivo-evolved C.

Snakebite envenoming in Africa remains widely neglected and demands multidisciplinary attention.

Snakebite envenoming can cause morbidity, permanent disability or death but treatment and prevention thereof remains highly inadequate in Africa. Overcoming structural and financial barriers that impede existing initiatives to improve medical management and mitigate human-snake conflict is urgently needed.

NHCl-induced metabolic acidosis increases the abundance of HCO transporters in the choroid plexus of mice.

Regulation of cerebrospinal fluid (CSF) pH and brain pH are vital for all brain cells. The acute regulation of CSF pH is dependent on the transport of HCO across the choroid plexus in the brain ventricles. Acute regulation in response to acidosis is dependent on H export and HCO import across the plasma membrane.

A Urine pH-Ammonium Acid/Base Score and CKD Progression.

Key Points: This study developed a urine acid/base score to assess tubular acid excretion capacity and identify early acid retention in CKD. The results show that early signs of acid retention (a low acid/base score) are associated with a higher risk for CKD progression. Future research should address if a low urine acid/base score can be improved and if this translates into clinically meaningful effects.