Publications by authors named "P B Pencharz"
Article Synopsis
- - Previous research suggested leucine needs for adults might range from 25 to 40 mg⋅kg⋅d, with new data indicating a potential requirement of up to 55 mg⋅kg⋅d, but this study specifically focused on young adult males using a method called indicator amino acid oxidation (IAAO).
- - The study involved ten healthy young males who were given varying amounts of leucine (from 10 to 75 mg⋅kg⋅d) over a three-day period to assess their leucine requirements while monitoring biochemical responses.
- - Results indicated that the average leucine requirement for these males was approximately 33.6 mg⋅kg⋅d, which supports prior findings and
Background: The protein quality of wheat is limited by its low content of the indispensable amino acid (AA) lysine and the metabolic availability (MA) of lysine in wheat bread for humans is unknown.
Objectives: The study objective was to determine the MA of lysine in whole wheat bread.
Methods: Five healthy young males (≤30 y, BMI <25 kg/m) were studied in a repeated-measures design using the indicator amino acid oxidation (IAAO) method, with L-[1-C] phenylalanine as the indicator.
Background: Dietary Reference Intake (DRI) Recommendations for total sulfur amino acids (TSAAs; methionine + cysteine) during pregnancy are based on factorial calculations using data from adult males. To date, no data exist on TSAA requirements obtained directly during pregnancy.
Objectives: The objective of this study was to examine whether TSAA requirements during early (11-20 wk) and late (31-40 wk) gestation in healthy females with singleton pregnancies are different than current recommendations, and different between early and late gestation using the indicator amino acid oxidation (IAAO) technique.
Background: Current recommendation for lysine in older adults, 30 mg/kg/d, is based on young adult data. Evidence suggests that amino acid requirements may differ between young and old adults with both sex and age having an effect in the elderly.
Objectives: This study aimed to define the lysine requirements in healthy older adults using the indicator amino acid oxidation (IAAO) method with L-[1-C] phenylalanine as the indicator and to compare the derived estimates based on age: 60-69 y and >70 y.
Background: Protein recommendations for older adults are based on nitrogen balance data from young adults. Physiological studies using the indicator amino acid oxidation method suggest they need 30% to 50% more protein than current recommendations. We herein present glutathione (GSH) as a physiological estimate of protein adequacy in older adults.
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