Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules.

The frequency of brain disease has increased significantly in the past years. After diagnosis, therapeutic options are usually limited, which demands the development of innovative therapeutic strategies. The use of antibody-drug conjugates (ADCs) is promising but highly limited by the existence of the blood-brain barrier (BBB).

Directionally solidified fabrication in planar geometry of AlO-ErAlO eutectic composite for thermophotovoltaic devices.

In this work AlO-ErAlO eutectic composite was manufactured in planar geometry departing from eutectic particles both produced by directional solidification using a CO laser system at rates of 180 and 720 mm/h. Microstructure and mechanical properties were investigated as a function of the growth rate. Homogeneous and interpenetrated microstructure was found with phase size strongly dependent on the growth rate, decreasing when the processing rate was increased.

Multiphase transformations controlled by ostwald's rule in nanostructured Ce(0.5)Zr(0.5)O(2) powders prepared by a modified Pechini route.

The thermal stability of nanostructured Ce(0.5)Zr(0.5)O(2) powders prepared by the Pechini method was studied on the nanometric scale by X-ray diffraction (XRD), energy-dispersive spectrometry (EDS), transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), and Raman techniques.

An electron paramagnetic resonance study of the tetragonally distorted [Formula: see text] ion in [Formula: see text] and [Formula: see text].

Chromium-doped [Formula: see text] and [Formula: see text] have been studied by both EPR and ENDOR spectroscopy. [Formula: see text] ions enter the fluorite structure in distorted substitution cation sites. In both matrices the distortion observed is tetragonal.