Publications by authors named "P B Morris"
Background: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
Article Synopsis
- The study explored the effects of a specific enzyme (FAEA) expressed in maize that targets the apoplast, focusing on its activity during the late stages of plant senescence and after storing the plant material.
- FAEA levels increased until the reproductive (R) stage but dropped during full leaf senescence (R+), while the enzyme remained stable even after six months of cold storage.
- The research found that FAEA expression led to decreased cell wall components like ferulates and improved the breakdown (saccharification) of plant material by enzymes, making it easier to extract sugars at later development stages.
Northern elephant seals (Mirounga angustirostris) have been integral to the development and progress of biologging technology and movement data analysis, which continue to improve our understanding of this and other species. Adult female elephant seals at Año Nuevo Reserve and other colonies along the west coast of North America were tracked annually from 2004 to 2020, resulting in a total of 653 instrument deployments. This paper outlines the compilation and curation process of these high-resolution diving and location data, now accessible in two Dryad repositories.
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