Publications by authors named "P B Mohite"
Article Synopsis
- Microneedle (MN) technology, particularly hydrogel-forming microneedles (HFMNs), offers an innovative non-invasive method for delivering drugs through the skin, promising significant improvements in treating various dermatological conditions like acne and psoriasis.!* -
- HFMNs are composed of small needles made from hydrophilic polymers that can penetrate the skin’s outer layer without harming underlying tissues; they absorb fluid to form a hydrogel that aids in transporting therapeutic agents directly into the dermal microcirculation.!* -
- The technology is designed to reduce patient discomfort compared to traditional needles, enabling better drug delivery with controlled release profiles, and it also allows for real-time monitoring of interstitial fluid, enhancing the
This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading.
View Article and Find Full Text PDFArticle Synopsis
- Stem cell therapy is an exciting area of medicine that could change how we treat cancer and brain diseases.
- Scientists are looking at special cells called Mesenchymal Stem Cells (MSCs), which can help either grow or fight tumors, and how they release tiny particles called exosomes that affect cancer growth.
- Genetic changes to stem cells might help deliver medicine directly to tumors, making this therapy promising for healing and managing diseases in the future.
This review explores the application of induced pluripotent stem cells (iPSCs) in regenerative medicine. The therapeutic significance of iPSC-derived cell therapy within regenerative medicine, emphasizes their reprogramming process and crucial role in cellular differentiation while setting the purpose and scope for the comprehensive exploration of iPSC-derived cell therapy. The subsequent sections intricately examine iPSC-derived cell therapy, unraveling the diverse derivatives of iPSCs and striking a delicate balance between advantages and limitations in therapeutic applications.
View Article and Find Full Text PDF