Digital Twin-Assisted Lightpath Provisioning and Nonlinear Mitigation in C+L+S Multiband Optical Networks.

Multiband (MB) optical transmission targets increasing the capacity of operators' optical transport networks. However, nonlinear impairments (NLI) affect each optical channel in the C+L+S bands differently, and, therefore, the routing and spectrum assignment (RSA) problem needs to be complemented with fast and accurate tools to consider the quality of transmission (QoT) within the provisioning process. This paper proposes a digital twin-assisted approach for lightpath provisioning to provide a complete solution for the RSA problem that ensures the required QoT in MB optical networks.

Examining structure-activity relationships of ManNAc analogs used in the metabolic glycoengineering of human neural stem cells.

This study defines biochemical mechanisms that contribute to novel neural-regenerative activities we recently demonstrated for thiol-modified ManNAc analogs in human neural stem cells (hNSCs) by comparing our lead drug candidate for brain repair, "TProp," to a "size-matched" N-alkyl control analog, "But." These analogs biosynthetically install non-natural sialic acids into cell surface glycans, altering cell surface receptor activity and adhesive properties of cells. In this study, TProp modulated sialic acid-related biology in hNSCs to promote neuronal differentiation through modulation of cell adhesion molecules (integrins α6, β1, E-cadherin, and PSGL-1) and stem cell markers.

Time series analysis of uptake and translocation of Cd and expression of transporter genes in nine Andrographis paniculata accessions.

Cadmium is a non-essential and toxic metal. Its presence in plants can have hazardous effects not only on the plants themselves but also on human health after consumption. A time-dependent experiment was conducted on nine accessions of A.

The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia.

The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2γ MEC1-based xenotransplantation model.

Recent insights on pattern recognition receptors and the interplay of innate immune responses against West Nile Virus infection.

The recent outbreaks of neurotropic West Nile Virus (WNV) in humans are of grave public health concern, requiring a thorough understanding of the host immune response to develop effective therapeutic interventions. Innate immunity contributes to the primary immune response against WNV infection aimed at controlling and eliminating the virus from the body. As soon as WNV infects the body, pattern recognition receptors (PRRs) recognize viral pathogen-associated molecular patterns, particularly viral RNA, and initiate innate immune responses.