An Isolable Azide Adduct of Titanium(II) Follows Bifurcated Deazotation Pathways to an Imide.

AdN (Ad = 1-adamantyl) reacts with the tetrahedral Ti complex [(Tp)TiCl] (Tp = hydrotris(3--butyl-5-methylpyrazol-1-yl)borate) to generate a mixture of an imide complex, [(Tp)TiCl(NAd)] (), and an unusual and kinetically stable azide adduct of the group 4 metal, namely, [(Tp)TiCl(γ-NAd)] (). In these conversions, the product distribution is determined by the relative concentration of reactants. In contrast, the azide adduct forms selectively when a masked Ti complex (N or AdNC adduct) reacts with AdN.

Symptom management strategies for men with early-stage prostate cancer: results from the Prostate Cancer Patient Education Program (PC PEP).

While the literature on prostate cancer health-related quality of life has grown extensively, little is known about symptom management strategies used by men to manage treatment-related side effects and the effectiveness of those strategies. We collected 628 symptom management reports from 98 men treated for localized prostate cancer. Participants were recruited from email lists and a prostate cancer clinic in Northern California.

Improving prediction of malignancy of cytologically indeterminate thyroid nodules.

Background: Fine-needle aspiration (FNA) is essential in the investigation of thyroid nodules. The British Thyroid Association guidelines recommend clarification of whether follicular nodules are probable follicular neoplasms that require surgical excision. This study assessed the value of the subclassification of cytologically indeterminate thyroid nodules into either follicular neoplasms or other pathology.

Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization.

Comparative genomic hybridization (CGH) makes it possible to detect losses and gains of DNA sequences along all chromosomes in a tumor specimen based on the hybridization of differentially labeled tumor and normal DNA to normal human metaphase chromosomes. In this study, CGH analysis was applied to the identification of genomic imbalances in 26 bladder cancers in order to gain information on the genetic events underlying the development and progression of this malignancy. Losses affecting 11p, 11q, 8p, 9, 17p, 3p, and 12q were all seen in more than 20% of the tumors.

Comparative clinical evaluation of freeze-dried skin allografts and autogenous gingival grafts in humans.

Freeze-dried skin (FDS) allografts and fresh autogenous free gingival grafts (FGG) were placed in five paired sites in four patients. Both types of grafts healed uneventfully. Evaluation over a 1-year period demonstrated no statistically or clinically significant differences between the FDS and FGG when: a) increase in the width of keratinized gingiva, b) decrease in recession, c) decrease in sulcus depth, k) gain in attachment level, or e) percent shrinkage of the graft were compared.