Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage.

Objective: We sought to measure the deformation of tibiofemoral cartilage immediately following a 3-mile treadmill run, as well as the recovery of cartilage thickness the following day. To enable these measurements, we developed and validated deep learning models to automate tibiofemoral cartilage and bone segmentation from double-echo steady-state magnetic resonance imaging (MRI) scans.

Design: Eight asymptomatic male participants arrived at 7 a.

Real-World Clinical Utility of a Methylated DNA Biomarker Assay on Samples Collected with a Swallowable Capsule-Balloon for Detection of Barrett's Esophagus (BE).

Barrett's Esophagus (BE) is the only known precursor for esophageal adenocarcinoma (EAC). Patients with multiple risk factors for BE/EAC are recommended for screening; however, few eligible patients undergo evaluation by endoscopy. EsoGuard (EG) is a commercially available biomarker assay used to analyze esophageal cells collected non-endoscopically with EsoCheck (EC) for the qualitative detection of BE/EAC.

'Setting the Benchmark' Part 3: Contextualising the Match Demands of Specialised Positions at the FIFA Women's World Cup Australia and New Zealand 2023.

This study aimed to benchmark the match demands of specialised positions at the FIFA Women's World Cup Australia and New Zealand 2023. With FIFA's official approval, all sixty-four games at the tournament were analysed using an optical tracking system alongside FIFA's Enhanced Football Intelligence metrics. During a typical match, defensive and central midfielders covered 5-15% more total distance than centre backs, wide defenders and centre forwards (P < 0.

Private, public, and bottled drinking water: Shared contaminant-mixture exposures and effects challenge.

Background: Humans are primary drivers of environmental-contaminant exposures worldwide, including in drinking-water (DW). In the United States, point-of-use DW (POU-DW) is supplied via private tapwater (TW), public-supply TW, and bottled water (BW). Differences in management, monitoring, and messaging and lack of directly-intercomparable exposure data influence the actual and perceived quality and safety of different DW supplies and directly impact consumer decision-making.

Estuarine dispersal of an invasive Holarctic predator (Esox lucius) confirmed in North America.

The capacity for a non-native species to become invasive largely hinges on existing dispersal capacity or adaptation of dispersal in new environments. Here we provide early evidence that invasive Northern Pike (Esox lucius), a Holarctic freshwater top predator, illegally introduced in the late 1950s into Southcentral Alaska, are now dispersing through estuarine corridors. This finding represents the first known documentation of estuary use and dispersal by Northern Pike in North America, exacerbating conservation concerns for already depressed populations of culturally and economically important species such as salmonids.