Publications by authors named "P B Arimondo"
Flavonoid derivatives are natural product analogues that have shown great interest for therapeutic applications as modulators of DNA methylation. In this article we report new synthesis pathways to access ten novel flavonoid derivatives (i.e.
View Article and Find Full Text PDFTargeting epigenetics is a new strategy to treat cancer and develop novel epigenetic drugs with anti-tumor activity. DNA methyltransferases transfer the methyl group from -adenosyl-L-methionine (SAM) to the cytosine residue in a CpG island, leading to the transcription silencing of the gene. Hypermethylation can frequently be observed in several tumor types.
View Article and Find Full Text PDFArticle Synopsis
- - Resistance to antimicrobial agents poses a significant global health threat, prompting the need for new treatment strategies targeting pathogens’ ability to manipulate host defenses, especially through epigenetic modification.
- - Legionella pneumophila, a Gram-negative intracellular bacterium, releases a specific methyltransferase named RomA that alters host epigenetic regulation by methylating H3 K14, helping the pathogen evade immune responses.
- - To inhibit RomA's activity, researchers developed a high-content imaging assay to screen chemical compounds targeting methyltransferases, successfully identifying potential inhibitors from an initial library of 477 compounds.
DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance by DNMT1, or if it has important additional functions. Using degron alleles, we show that UHRF1 depletion causes a much greater loss of DNA methylation than DNMT1 depletion.
View Article and Find Full Text PDF