Publications by authors named "P B Acosta"

This is a qualitative systematic review in which we investigated barriers and enablers influencing dietary behavior change after metabolic bariatric surgery (MBS). Database searches retrieved publications reporting perceived factors influencing dietary behavior change post-MBS. Data (quotes, survey results, interpretative summaries) were extracted and analyzed using combined deductive and inductive thematic analyses.

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Although tryptophan (Trp) is the largest and most structurally complex amino acid, it is the least abundant in the proteome. Its distinct indole ring and high carbon content enable it to generate various biologically active metabolites such as serotonin, kynurenine (Kyn), and indole-3-pyruvate (I3P). Dysregulation of Trp metabolism has been implicated in diseases ranging from depression to cancer.

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Head and neck squamous cell carcinoma (HNSCC) is a complex cancer requiring a multidisciplinary approach. For patients with locally or regionally advanced disease, surgery and/or radiation are the cornerstones of definitive treatment. Medical therapy plays an important adjunct role in this setting, typically consisting of a platinum-based regimen given as induction, concurrent, or adjuvant treatment.

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Background: Humoral immune response against the pre-fusion (pre-F) conformation of respiratory syncytial virus (RSV) F protein has been proposed to play a protective role against infection. An RSV pre-F maternal vaccine has been recently approved in several countries to protect young infants against RSV. We aimed to assess serum IgG titers against the pre-F and post-F conformations of RSV F protein and their association with life-threatening RSV disease (LTD) in previously healthy infants.

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Article Synopsis
  • The study investigates the clinical and radiologic characteristics that can predict clinically significant prostate cancer (csPCa) in men with PI-RADS 3 lesions identified via multiparametric MRI, addressing an unmet need for risk-adapted approaches in clinical practice.
  • Data from 230 patients revealed that factors like PSA density (PSAd) and 4Kscore were significant predictors of csPCa, with PSAd showing the best performance in terms of prediction capability.
  • The findings suggest that combining PSAd with clinical factors is more effective for risk stratification of csPCa in patients with PI-RADS 3 lesions, particularly highlighting the predictive strength of 4Kscore in those with low PSAd.
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