Publications by authors named "P Auvinen"
Background: Assisted reproductive technology (ART) has been associated with increased risks for growth disturbance, disrupted imprinting as well as cardiovascular and metabolic disorders. However, the molecular mechanisms and whether they are a result of the ART procedures or the underlying subfertility are unknown.
Methods: We performed genome-wide DNA methylation (EPIC Illumina microarrays) and gene expression (mRNA sequencing) analyses for a total of 80 ART and 77 control placentas.
The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of concern (VOCs) that significantly affect global health. This study aims to investigate how these VOCs affect host cells at proteome level to better understand the mechanisms of disease. To achieve this, we first analyzed the (phospho)proteome changes of host cells infected with Alpha, Beta, Delta, and Omicron BA.
View Article and Find Full Text PDFUnlabelled: () DSM 20271 is a bacterium known for its ability to thrive in diverse environments and to produce vitamin B12. Despite its anaerobic preference, recent studies have elucidated its ability to prosper in the presence of oxygen, prompting a deeper exploration of its physiology under aerobic conditions. Here, we investigated the response of DSM 20271 to aerobic growth by employing comparative transcriptomic and surfaceome analyses alongside metabolite profiling.
View Article and Find Full Text PDFArticle Synopsis
- - The endophytic bacterium Serratia plymuthica A30 is an effective biocontrol agent for potato tubers, showing strong resistance against soft rot pathogens like Dickeya solani, especially in cold conditions.
- - A30 triggers early defense mechanisms in potato tubers by enhancing microbial recognition and activating detoxification pathways, while later inhibiting stress-related gene expression to promote a symbiotic relationship.
- - The interaction between A30 and potato tubers suggests benefits such as maintaining dormancy and delaying sprouting, which could improve tuber durability during storage, highlighting its potential in managing soft rot pathogens.
Importance: The standard adjuvant treatment for patients with ERRB2-positive breast cancer is chemotherapy plus 1 year of trastuzumab. Shorter durations of trastuzumab administration improve cardiac safety, but more information is needed about their effect on survival.
Objective: To compare survival outcomes after 9-week vs 1-year administration of trastuzumab with the same adjuvant chemotherapy.