Publications by authors named "P Asfar"
Article Synopsis
- The study aimed to determine if setting a lower mean arterial blood pressure (MAP) target could reduce 90-day all-cause mortality in critically ill patients with vasodilatory shock compared to a higher MAP target.
- Researchers performed a meta-analysis of randomized controlled trials involving 3,352 patients across several countries, using statistical models to analyze the data.
- The results suggested that a lower MAP target might be associated with a slight reduction in mortality risk, but the evidence is uncertain, indicating that it does not rule out the possibility of potential harm from lower targets.
Severe acute respiratory syndrome (SARS) and acute respiratory distress syndrome (ARDS) are often considered separate clinico-radiological entities. Whether these conditions also present a single process-specific systemic biomolecular phenotype and how this relates to patient outcomes remains unknown. A prospective cohort study was conducted, including adult patients admitted to the ICU and general floors for COVID-19-related (COVID+) or non-COVID-19-related (COVID-) acute respiratory failure during the main phase of the pandemic.
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- Researchers investigated the effect of losartan, an angiotensin receptor blocker, on 28-day mortality in hospitalized COVID-19 patients compared to usual care, due to its potential impact on angiotensin levels.
- The study was stopped early due to safety concerns, showing that adverse events and hypotension were significantly higher in the losartan group (39.8% SAEs and 30.4% hypotension) versus the control group (27.2% SAEs and 15.3% hypotension).
- There was no significant difference in 28-day mortality (6.5% for losartan vs. 5.9% for usual care), indicating that ARBs should be used cautiously in this patient population to
Article Synopsis
- Endotracheal intubation (ETI) is crucial for critically ill patients
- , but it has risks like hypoxemia; preoxygenation is used to enhance safety but can have unreliable monitoring through standard pulse oximeters (SpO2).
- The Oxygen Reserve Index (ORI)
- is proposed as a more reliable continuous measure during preoxygenation, targeting an ORI value of at least 0.6 over one minute instead of the standard SpO2 100% goal to improve outcomes.
- A trial with 950 critically ill adults
- will compare ORI monitoring against standard SpO2 monitoring during ETI; outcomes include the lowest SpO2 during intubation and cognitive
Background: Critical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience and its associations with PTSD and quality of life, and also identified factors associated with greater resilience.
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