Perceptions and experiences of directly observed treatment in tuberculosis: insights from a mixed-methods cross-sectional study.

Objective: The demanding nature and psychosocial burdens of directly observed treatment (DOT) have opened a path to alternative strategies such as video-observed therapy (VOT), which offers comparable treatment outcomes and patient satisfaction while potentially saving time and reducing costs. The objective of this study was to evaluate the perceptions and experiences of patients and health care professionals regarding DOT and other treatment strategies implemented in Portugal.

Methods: Patients with a confirmed diagnosis of tuberculosis, treated at the Vila Nova de Gaia Outpatient Tuberculosis Centre in the last two years, were asked to complete a brief questionnaire, as were health care professionals working in the northern region of Portugal.

The rehabilitation of children with brain tumors using exergames: a scoping review protocol.

Objective: To map the literature on the use of exergames in the rehabilitation of school-age children with brain tumors, in any context.

Method: Scoping review protocol developed using the recommendations of the Joanna Briggs Institute. The search will include aggregators, databases, indexes, repositories, and research browsers, without limitation as to the year of publication.

Exploring the structure and nucleic acid interactions of the Leishmania sp. telomerase reverse transcriptase N-terminal region.

Leishmaniasis is a neglected tropical disease caused by protozoans of the Leishmania genus, against which no effective treatment or control is available. Like other eukaryotes, parasite telomeres are maintained by telomerase, a ribonucleoprotein complex vital for genome stability. Its protein component, TERT (telomerase reverse transcriptase), presents four structural and functional domains, with the TEN (Telomerase N-terminal) and TRBD (Telomerase RNA-binding) located at its N-terminal.

Trophic Structure and Isotopic Niche of Invaded Benthic Communities on Tropical Rocky Shores.

When a species is introduced in a new location, it is common for it to establish itself when it finds favorable conditions in the receptor community with regard to interspecific interactions with native species. The azooxanthellate corals coccinea and are invasive species introduced in the Caribbean Sea, the Gulf of Mexico, and the Brazilian Southwest Atlantic. They are successful competitors for space, have multiple reproductive modes, and have high larval dispersion and recruitment, but studies on food and trophic relationships of the genus are still scarce.

High percentage of immune Th1 and Tc1 cells infiltrating visceral adipose tissue in people with obesity.

Subcutaneous (SAT) and visceral (VAT) adipose tissue dysfunction during the obesity onset can lead to increased expression of inflammatory molecules, and consequently to immune cell infiltration. The aim was to deeply characterize the T cells, those infiltrating SAT and VAT, compared to peripheral blood (PB), in individuals undergoing bariatric surgery. Forty-two adult individuals were recruited, SAT and VAT samples were collected.