An Overview on Renal and Central Regulation of Blood Pressure by Neuropeptide FF and Its Receptors.

Neuropeptide FF (NPFF) is an endogenous octapeptide that was originally isolated from the bovine brain. It belongs to the RFamide family of peptides that has a wide range of physiological functions and pathophysiological effects. NPFF and its receptors, NPFFR1 and NPFFR2, abundantly expressed in rodent and human brains, participate in cardiovascular regulation.

Development of Self-Powered Energy-Harvesting Electronic Module and Signal-Processing Framework for Wearable Healthcare Applications.

A battery-operated biomedical wearable device gradually assists in clinical tasks to monitor patients' health states regarding early diagnosis and detection. This paper presents the development of a self-powered portable electronic module by integrating an onboard energy-harvesting facility for electrocardiogram (ECG) signal processing and personalized health monitoring. The developed electronic module provides a customizable approach to power the device using a lithium-ion battery, a series of silicon photodiode arrays, and a solar panel.

Genetic variants of accessory proteins and G proteins in human genetic disease.

We present a series of three articles on the genetics and pharmacogenetics of G protein- coupled receptors (GPCR). In the first article, we discuss genetic variants of the G protein subunits and accessory proteins that are associated with human phenotypes; in the second article, we build upon this to discuss "G protein-coupled receptor (GPCR) gene variants and human genetic disease" and in the third article, we survey "G protein-coupled receptor pharmacogenomics". In the present article, we review the processes of ligand binding, GPCR activation, inactivation, and receptor trafficking to the membrane in the context of human genetic disease resulting from pathogenic variants of accessory proteins and G proteins.

Reliability of the documented blood group in motor vehicle driving license in Kerala, India - A public health concern?

Introduction: Blood groups documented in motor vehicle driving licenses can provide quick information during emergency transfusion requirements and imbibe self-awareness about one's blood group. The tendency of applicants to mention blood groups without verification during the application may result in incorrect documentation of blood groups in their driving license. The study aims to assess the reliability of the blood groups in driving licenses and their association with sociodemographic variables.

Factors Associated with Lipoprotein(a) Testing Among Multiethnic Individuals.

Background: Lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and clinical guidelines recommend incorporating Lp(a) testing in routine care.

Objective: Examine real-world, contemporary clinical testing patterns of Lp(a) among multiethnic populations.

Design: In this nested case-control study, we assessed the prevalence and factors associated with Lp(a) testing within a large Northern Californian health system between 2010 and 2021.