Publications by authors named "P Annie Weisner"
was originally discovered as the gene disrupted by a translocation in human twins with Autism spectrum disorder, intellectual disability, and epilepsy. Since that initial finding, -linked mutations and variants have been associated with a very broad array of neuropsychiatric disorders, sugg esting that is required for fundamental steps of neurodevelopment. However, genotype-phenotype correlations in this region are complicated, because most mutations could also involve neighboring genes.
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- Agonistic encounters trigger significant changes in gene expression that influence future behavior, and the study examines this phenomenon across various animal species.
- A specific transcriptional program was identified, highlighting the role of transcription factors, energy metabolism, and developmental signaling genes in response to social challenges like aggression.
- The researchers utilized gene expression and chromatin landscape data from different brain regions in mice, revealing a complex pattern of neural signaling and highlighting the regulatory role of the metabolic and developmental factor ESRRA, which is expressed in both oligodendrocytes and neurons.
Article Synopsis
- Certain complex traits are repeatedly observed across different species due to evolutionary processes, and this study explores whether shared molecular mechanisms underlie similar social behaviors.
- Using a comparative genomics approach on house mice, stickleback fish, and honey bees, the researchers found that similar brain functions related to hormone signaling and energy metabolism were activated during territory intrusion across these species.
- The study highlighted conserved genetic elements, particularly transcription factors linked to neural development, suggesting these "toolkits" are involved in the independent evolution of social behaviors in diverse organisms.
Pax6 encodes a transcription factor with key roles in the development of the pancreas, central nervous system, and eye. Gene expression is orchestrated by several alternative promoters and enhancer elements that are distributed over several hundred kilobases. Here, we describe a reciprocal translocation, called 1Gso, which disrupts the integrity of transcripts arising from the 5'-most promoter, P0, and separates downstream promoters from enhancers active in pancreas and eye.
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