Publications by authors named "P Ang"
Introduction: Holistic Approach in Lowering and Tracking Chronic Kidney Disease (HALT-CKD) is a nationwide programme that was introduced in 2017 to combat CKD in Singapore. This study aims to evaluate outcomes of the HALT-CKD programme and identify factors influencing disease progression among early CKD patients.
Method: We conducted a retrospective cohort study involving adult patients aged 21 to 80 with CKD stages G1-G3A, recruited from 5 Singapore polyclinics between 2017 and 2018.
Article Synopsis
- The study examines the shift in healthcare policies for migrant workers in Singapore from focusing primarily on workplace injuries to a broader approach emphasizing accessibility and affordability of health services, especially during the COVID-19 pandemic.
- A survey conducted with over 1,000 male migrant workers revealed that while a high percentage felt they could access healthcare and were satisfied with costs, a significant number did not utilize these services regularly due to low perceived need.
- The research aims to identify gaps in health service delivery and help policy makers enhance the effectiveness of healthcare initiatives for migrant workers, particularly through better understanding of their health-seeking behaviors and awareness of new financing plans.
Patients with brain metastases (BM) face a 90% mortality rate within one year of diagnosis and the current standard of care is palliative. Targeting BM-initiating cells (BMICs) is a feasible strategy to treat BM, but druggable targets are limited. Here, we apply Connectivity Map analysis to lung-, breast-, and melanoma-pre-metastatic BMIC gene expression signatures and identify inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in the de novo GTP synthesis pathway, as a target for BM.
View Article and Find Full Text PDFAnaphylaxis post-COVID-19 vaccinations in Singapore.
Singapore Med J
September 2024
Introduction: Anaphylaxis was the first serious adverse event (AE) of special interest surfaced in Singapore following coronavirus disease 2019 (COVID-19) vaccination. Individuals who developed physician-diagnosed severe allergic reactions to the mRNA vaccines would be medically ineligible for mRNA vaccines and offered non-mRNA alternatives. This paper describes anaphylaxis reports received by the Health Sciences Authority (HSA) and presents a review of individuals who received heterologous COVID-19 vaccination.
View Article and Find Full Text PDFPurpose: Bleeding is an important health outcome of interest in epidemiological studies. We aimed to develop and validate rule-based algorithms to identify (1) major bleeding and (2) all clinically relevant bleeding (CRB) (composite of major and all clinically relevant nonmajor bleeding) within real-world electronic healthcare data.
Methods: We took a random sample (n = 1630) of inpatient admissions to Singapore public healthcare institutions in 2019 and 2020, stratifying by hospital and year.