Spatial expression of HER2, NECTIN4, and TROP-2 in Muscle-Invasive Bladder Cancer and metastases: Implications for pathological and clinical management.

Muscle-invasive bladder cancer (MIBC) presents significant treatment challenges. Antibody-drug conjugates (ADCs) targeting HER2, TROP-2, and NECTIN4 offer promising therapeutic options. This study examined the spatial expression of HER2, TROP-2, and NECTIN4 in MIBC and metastases, their association with molecular subtypes, and clinical outcomes.

Magnetically shielded high-resolution visual stimulation for OPM-MEG applications.

Many magnetoencephalography (MEG) experiments require visual stimulation (VS) inside a magnetically shielded room (MSR). For conventional MEG utilizing superconducting quantum interference devices (SQUIDs), the participant's head must stay within the semi-spherical surface of a cryogenic storage Dewar. This design allows to have many SQUID sensors as close as possible to the head in order to achieve good signal quality.

Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7.

Purpose: The purpose of this study was to evaluate the feasibility and utility of optical coherence tomography (OCT)-based, targeted microperimetry grids in assessing focal lesions in intermediate age-related macular degeneration (iAMD).

Methods: The multicenter, prospective PINNACLE study enrolled 395 patients with iAMD aged 55 to 90 years across 12 international sites. Participants underwent imaging, including OCT and microperimetry, every 4 to 12 months over 3 years.

Features of intermediate and late dry age-related macular degeneration on adaptive optics ophthalmoscopy: Pinnacle Study Report 8.

Background/objectives: Adaptive optics ophthalmoscopy (AOO) has the potential to provide insights into AMD pathology and to assess the risk of progression. We aim to utilise AOO to describe detailed features of intermediate AMD and to characterise microscopic changes during atrophy development.

Subjects/methods: Patients with intermediate AMD were recruited into PINNACLE, a prospective observational cohort study.