Publications by authors named "P Andel"
ASO Visual Abstract: Defining and Predicting Early Recurrence for Optimal Treatment Strategies in Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer--An International Multicenter Study.
Joseph R Habib Ammar A Javed Ingmar F Rompen Camila Hidalgo Salinas Anthony Sorrentino Paul C M Andel
Ann Surg Oncol
January 2025
Defining and Predicting Early Recurrence for Optimal Treatment Strategies for Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: An International Multicenter Study.
Joseph R Habib Ammar A Javed Ingmar F Rompen Camila Hidalgo Salinas Anthony Sorrentino Paul C M Andel
Ann Surg Oncol
December 2024
Article Synopsis
- This study investigates early recurrence in patients with pancreatic ductal adenocarcinoma (PDAC) derived from intraductal papillary mucinous neoplasm (IPMN), aiming to identify predictors to help guide patient management.
- The research found that early recurrence is defined as occurring within 10.5 months post-surgery, affecting 38% of patients who experienced recurrence, with CA19-9 levels and N2 disease being significant predictors.
- Adjuvant chemotherapy showed a survival advantage only for high-risk patients, highlighting the importance of risk stratification for better treatment outcomes.
Objective: The aim of this study was to evaluate the different phases of the learning curve for robotic distal pancreatectomy (RDP) in international expert centers.
Summary Background Data: RDP is an emerging minimally invasive approach; however, only limited, mostly single center data are available on its safe implementation, including the learning curve.
Methods: Consecutive patients undergoing elective RDP from 16 expert centers across three continents were included to assess the learning curve.
Article Synopsis
- International guidelines for imaging follow-up after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC) are inconsistent, leading to varied follow-up strategies globally.
- The study aimed to compare clinical outcomes, including treatment for recurrence and survival rates, between patients who received either symptomatic follow-up or routine imaging after PDAC surgery across 33 international centers.
- A total of 333 patients were analyzed, showing that 29% had symptomatic follow-up while 71% underwent routine imaging, with overall survival rates being examined through statistical methods to identify the impact of the follow-up strategy on patient outcomes.
Article Synopsis
- The study investigates whether total pancreatectomy (TP) provides better oncological outcomes than partial pancreatectomy (PP) for patients with high-risk IPMN-associated cancer, focusing on local recurrence and secondary progression.
- It compares data from 359 patients, showing that while TP offers improved local disease-free survival (local-DFS), there is no significant difference in overall survival (OS) between TP and PP.
- The findings suggest that TP could be more beneficial for younger patients who are likely to benefit from reduced recurrence risk, while elderly patients may not see the same advantage in OS.