Fumaric acid ester-induced T-cell lymphopenia in the real-life treatment of psoriasis.

Background: Fumaric acid esters (FAEs) are used to treat psoriasis and are known to cause lymphopenia in roughly 60% of the patients. Much remains to be elucidated about the biological effects of FAEs on lymphocytes.

Objective: To evaluate the influence of long-term FAE (Fumaderm ) treatment on peripheral blood CD4 and CD8 T cells, CD19 B cells and CD56 natural killer (NK) cells in psoriasis.

Long-term real-life safety profile and effectiveness of fumaric acid esters in psoriasis patients: a single-centre, retrospective, observational study.

Background: Fumaric acid esters (FAEs) are an established systemic treatment for moderate-to-severe psoriasis. However, the long-term clinical safety and effectiveness of continuous FAE monotherapy and combination therapy have not been established.

Objective: To examine the long-term safety and effectiveness of FAEs as monotherapy and in combination with phototherapy or methotrexate in patients with psoriasis treated at a single centre in Germany.

Occlusion rate, venous symptoms and patient satisfaction after radiofrequency-induced thermotherapy (RFITT®): are there differences between the great and the small saphenous veins?

Background: Previous studies on the therapy of insufficient saphenous veins mainly compare different treatment methods. Only a few investigate differences of a specific treatment option between the great (GSV) and the small saphenous vein (SSV). The aim of this study was to evaluate the efficacy, clinical improvement and patient satisfaction after radiofrequency-induced thermotherapy (RFITT®) with regard to the treated vein.

Neurological disorders in patients with bullous pemphigoid: clinical and experimental investigations.

Background: Previous studies have shown that patients with bullous pemphigoid (BP) are more likely to have neurological diseases (ND).

Objectives: To compare clinical findings in BP patients with and without ND and to investigate BP180 autoantibody binding in different neuronal tissues of mammalians.

Methods: Our database was searched for clinical findings of in-patients with the definitive diagnosis of BP.