Publications by authors named "P Alnaes-Katjavivi"
Objective: Increasing numbers of pregnancies are complicated by pregestational diabetes mellitus, especially type 2 diabetes (T2DM). Some studies have reported similar or greater risks of adverse pregnancy outcomes among women with T2DM relative to type 1 diabetes (T1DM). We aimed to compare the risk of four pregnancy complications: pre-eclampsia, preterm delivery, macrosomia, and perinatal mortality, in pregnant women with T2DM vs T1DM in high-income countries.
View Article and Find Full Text PDFBackground: Hypertensive disorders of pregnancy (preeclampsia, gestational hypertension, and chronic hypertension), diabetes mellitus, and placental dysfunction confer an increased risk of long-term maternal cardiovascular disease. Preeclampsia is also associated with acute atherosis that involves lesions of uteroplacental spiral arteries, resembling early stages of atherosclerosis. Serum amyloid A1 is involved in hypercoagulability and atherosclerosis and may aggregate into amyloid-aggregations of misfolded proteins.
View Article and Find Full Text PDFArticle Synopsis
- Decidua basalis, the layer of the uterus involved in pregnancy, is crucial for maternal-fetal interaction and is linked to a condition called acute atherosis, which affects spiral arteries and is often seen in complications like preeclampsia and fetal growth restriction.
- Researchers have developed a vacuum suction method to obtain decidua basalis tissue for studying acute atherosis and how it relates to inflammation in pregnancy, since sampling this tissue has been difficult previously.
- The study suggests that various inflammatory and vascular factors contribute to acute atherosis formation, and proposes a link between fetal microchimerism in women with preeclampsia and risks of cardiovascular issues later in life.