The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran.

Background: Diabetes comprises a serious disease with significant growth in the number of cases in recent years. Here, we cover the gap in information between leptin (LEP) and type 1 diabetes in the Iranian population.

Aim: To recognise LEP G2548A and LEP receptor Q223R polymorphisms in Iranian people and their association with type 1 diabetes susceptibility.

The Effect of L. Fruit Juice on the Blood Sugar Level and Other Serum Parameters in Patients with Diabetes Type 2.

Background: The effect of the daily consumption of (Noni) fruit juice on the physiological status of patients with diabetes type 2 (DT2) was tested over a period of two months.

Methods: (Noni) fruit juice (NFJ), 2 ml per kg bw per day, was consumed by twenty patients with DT2 after they underwent a standard treatment regimen including carbohydrate reduced diet and treatment with an antidiabetic drug and/or insulin. NFJ consumption started only after no further improvement was achieved.

Comparison Between Minimally Invasive Surgery and Conventional Open Surgery for Patients With Spinal Metastasis: A Prospective Propensity Score-Matched Study.

Study Design: Prospective propensity score-matched study.

Objective: To compare the outcomes of minimal invasive surgery (MIS) and conventional open surgery for spinal metastasis patients.

Summary Of Background Data: There is lack of knowledge on whether MIS is comparable to conventional open surgery in treating spinal metastasis.

Sunitinib treatment reduces tumor growth and limits changes in microvascular properties after minor surgical intervention in an in vivo model of secondary breast cancer growth in bone.

Background And Objectives: Surgical interventions can alter the balance between pro- and anti-angiogenic growth factors and thereby modulate tumor growth. Since the microcirculatory properties of tumors underlie organ-specific differences, the microhemodynamic characteristics of bone metastasis have not yet been fully described. Angiogenesis inhibitors are increasingly being used to treat advanced stages of cancer.

Chemokine profile of disc degeneration with acute or chronic pain.

Object: Disc-related disorders such as herniation and chronic degenerative disc disease (DDD) are often accompanied by acute or chronic pain. Different mediators have been identified in the development of radicular pain and DDD. Previous studies have not analyzed individual cytokine profiles discriminating between acute sciatic and chronic painful conditions, nor have they distinguished between different anatomical locations within the disc.