Continuous alternating inhaled antibiotics for chronic pseudomonal infection in cystic fibrosis.

Background: Inhaled antibiotics are standard of care for treating chronic pseudomonal respiratory infections in cystic fibrosis patients, initially approved for intermittent administration. However, use of continuous inhaled antibiotic regimens of differing combinations is growing.

Methods: This double-blind trial compared continuous alternating therapy (CAT) to an intermittent treatment regimen.

Effective method for quantifying respiratory effective method for quantifying respiratory subsequent marker of anxiety.

Ambulatory respiratory data was gathered using inductive lethysmography technology with synchronous ECG(LifeShirte , VivoMetrics, Ventura, CA) during a study to evaluate the effect of an anxiolytic on heart rate variability and respiratory pattern as indicators of anxiety state. Positive control (PCR; post-marketing, broadly prescribed anxiolytic)and placebo (PBO) data was included in the analysis. Tidal volume waveforms were the result of a weighted sum of the abdominal and rib cage IP bands according to the qualitative diagnostic calibration method.

Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis.

Objective: To elucidate sources of variability in the estimate of treatment effects in a successful phase 3 trial in severe sepsis and to assess their implications on the design of future clinical trials.

Design: Retrospective evaluation of prospectively defined subgroups from a large phase 3, placebo-controlled clinical trial (PROWESS).

Setting: The study involved 164 medical centers.

Threshold effects of respiratory muscle work on limb vascular resistance.

The purpose of this study was to determine whether the human diaphragm, like limb muscle, has a threshold of force output at which a metaboreflex is activated causing systemic vasoconstriction. We used Doppler ultrasound techniques to quantify leg blood flow (Q(L)) and utilized the changes in mouth twitch pressure (DeltaP(M)T) in response to bilateral phrenic nerve stimulation to quantify the onset of diaphragm fatigue. Six healthy male subjects performed four randomly assigned trials of identical duration (8 +/- 2 min) and breathing pattern [20 breaths/min and time spent on inspiration during the duty cycle (time spent on inspiration/total time of one breathing cycle) was 0.