Optimisation and evaluation of long circulating Ru-SLNs carrier for targeting melanoma cells.

The aim of study was to prepared and evaluated rutin-loaded solid-lipid-nanoparticles (Ru-SLNs) gel for treatment of melanoma cells. SLNs were prepared by ultrasonication method through optimisation and evaluated their mean-diameter, PDI, zeta-potential, morphology, entrapment-efficiency, drug-loading, interaction by FTIR, in vitro skin permeation, stability, antioxidant/MTT assay and fluorescence microscopic. Further developed Ru-SLNs was incorporated into gel and characterised their physicochemical properties, drug contents, in vitro diffusion, ex vivo permeation and retention studies in human cadaver skin.

Noise pollution mitigation and control in urban areas near international borders through 2D noise mapping.

Noise pollution is defined as any disturbing or unwanted sound that disrupts or harms human health or wildlife. Noise pollution can have profound effects on both human health and the environment. For humans, exposure to excessive noise levels has been linked to a range of health issues, including hearing damage, stress, and sleep disturbances.

Characterization and analysis of municipal solid waste generated in the semi-urban region of Thanamandi, Jammu and Kashmir (J&K), India: a basis for developing a suitable waste management approach.

Population growth, urbanization, lifestyle changes, and consumption patterns increase waste management problems in Thanamandi town. The waste generation rate in Thanamandi town is expanding, and there is a need for adequate waste segregation, recycling programs, and sorting facilities. Therefore, this study aims to estimate the municipal solid waste (MSW) generation rate in Thanamandi town, including an analysis of its composition.

Synthesis, characterization, and bioactivity of Cu(II), Fe(II), Co(II), Ni(II), and Mn(II) complexes with benzilmonoximethiocarbohydrazide-O-methoxybenzaldehyde: experimental and computational insights.

In this study, a novel ligand, benzilmonoximethiocarbohydrazide-O-methoxybenzaldehyde (HBMToMB), was synthesized and subsequently complexed with Cu(II), Fe(II), Co(II), Ni(II), and Mn(II) ions. The metal complexes were comprehensively characterized using techniques such as NMR, IR, Mass Spectrometry, UV-Vis, elemental analysis (CHNS), and magnetic susceptibility measurements. The complexes exhibited superior antibacterial and antifungal activity compared to the free ligand.

Development, Analysis, and Determination of Pharmacokinetic Properties of a Solid SMEDDS of Voriconazole for Enhanced Antifungal Therapy.

Background: Voriconazole is an antifungal drug, which is classified under Bio-Classification System-II and has low water solubility (0.71 mg/mL) and high permeability. Hardly any endeavors have been made to increase the bioavailability of voriconazole.