Publications by authors named "P Agape"
Belantamab mafodotin (BM) is an anti-BCMA antibody-drug conjugate (GSK2857916) that represents an alternative option in multiple myeloma. We sought to assess the efficacy and safety of BM in a real-world setting in patients who benefited from an early access program. We conducted an observational, retrospective, multicenter study.
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- - Most relapses of primary central nervous system lymphoma (PCNSL) typically occur in the brain and have a poor prognosis, while isolated intraocular relapses (IIORs) are rare and not well understood.
- - A study analyzed 55 PCNSL patients with IIOR and found that a significant number had high IL-10 levels in their eye fluid, and the majority received systemic chemotherapy, with some undergoing high-dose chemotherapy followed by stem cell transplantation (HCT-ASCT).
- - After an average follow-up of nearly 6 years, 76% of patients relapsed, especially those who didn't have HCT-ASCT; however, prognosis was better for IIOR compared to brain relapses, undersc
The optimal consolidation strategy for primary central nervous system lymphoma (PCNSL) remains controversial. Preventing radio-induced neurotoxicity of consolidation treatment through reduced-dose whole-brain radiotherapy (rdWBRT) at a dose of 23.4 Gy is an interesting alternative to conventional WBRT in patients aged <60 years.
View Article and Find Full Text PDFObjectives: To compare brain MRI findings in progressive multifocal leukoencephalopathy (PML) associated to rituximab and natalizumab treatments and HIV infection.
Materials And Methods: In this retrospective, multicentric study, we analyzed brain MRI exams from 72 patients diagnosed with definite PML: 32 after natalizumab treatment, 20 after rituximab treatment, and 20 HIV patients. We compared T2- or FLAIR-weighted images, diffusion-weighted images, T2*-weighted images, and contrast enhancement features, as well as lesion distribution, especially gray matter involvement.
Objective: Real-life studies on patients with primary CNS lymphoma (PCNSL) are scarce. Our objective was to analyze, in a nationwide population-based study, the current medical practice in the management of PCNSL.
Methods: The French oculo-cerebral lymphoma network (LOC) database prospectively records all newly diagnosed PCNSL cases from 32 French centers.