Publications by authors named "P A Zalloua"
Informational rescaling of PCA maps with application to genetic distance.
Comput Struct Biotechnol J
December 2024
Principal Component Analysis (PCA) is a powerful multivariate tool allowing the projection of data in low-dimensional representations. Nevertheless, datapoint distances on these low-dimensional projections are challenging to interpret. Here, we propose a computationally simple heuristic to transform a map based on standard PCA (when the variables are asymptotically Gaussian) into an entropy-based map where distances are based on mutual information (MI).
View Article and Find Full Text PDFWhile a broad consensus about the first successful migration modern humans out of Africa seems established, the peopling of Arabia remains somewhat enigmatic. Identifying the ancestral populations that contributed to the gene pool of the current populations inhabiting Arabia and the impact of their contributions remains a challenging task. We investigate the genetic makeup of the current Yemeni population using 46 whole genomes and 169 genotype arrays derived from Yemeni individuals from all geographic regions across Yemen and 351 genotype arrays derived from neighboring populations providing regional context.
View Article and Find Full Text PDFArticle Synopsis
- Severe coronary artery disease (CAD) is linked to serious complications like heart attacks and angina, and this study focuses on understanding the genetic factors associated with severe and multi-vessel CAD.
- Researchers analyzed data from 1,900 patients with severe CAD and 1,056 healthy controls, identifying 14 genetic variants related to severe disease and finding specific associations based on age.
- Notably, the PHACTR1 gene variant increases the risk for younger individuals, while another variant in APOC1/APOE decreases risk for older adults, highlighting how genetic differences can influence CAD severity and potentially inform personalized treatment strategies.
Lebanon's rich history as a cultural crossroad spanning millennia has significantly impacted the genetic composition of its population through successive waves of migration and conquests from surrounding regions. Within modern-day Lebanon, the Koura district stands out with its unique cultural foundations, primarily characterized by a notably high concentration of Greek Orthodox Christians compared to the rest of the country. This study investigates whether the prevalence of Greek Orthodoxy in Koura can be attributed to modern Greek heritage or continuous blending resulting from the ongoing influx of refugees and trade interactions with Greece and Anatolia.
View Article and Find Full Text PDFAims: Hypertension (HTN) and Type 2 Diabetes (T2D) often coexist, therefore understanding the relationship between both diseases is imperative to guide targeted prevention/therapy. This study aims to explore the relationship between HTN and T2D using genome-wide association study (GWAS) analysis and biochemical data to understand the implication of both clinical and genetic factors in these pathologies.
Methods: A total of 2,876 patients were enrolled.