Improving Chinese hamster ovary host cell protein ELISA using Ella: an automated microfluidic platform.

Chinese hamster ovary (CHO) cells are a mammalian cell line used in the production of therapeutic proteins. Host cell proteins (HCPs) are process-related impurities that are derived from the host cell expression system. During biopharmaceutical drug development, removal of HCPs is required.

How Does Diabetes Affect Daily Life? A Beyond-A1C Perspective on Unmet Needs.

Given the progressive nature of type 2 diabetes, treatment intensification is usually necessary to maintain glycemic control. However, for a variety of reasons, treatment is often not intensified in a timely manner. The combined use of basal insulin and a glucagon-like peptide-1 receptor agonist is recognized to provide a complementary approach to the treatment of type 2 diabetes.

Prospective observational measurement of tracheal tube cuff pressures in the emergency department.

Background: Tracheal mucosal blood flow is impaired when tracheal tube cuff pressure is above 30 cm of water, with the potential for tracheal mucosal necrosis. Previous studies have found excessive cuff pressures in simulated patients intubated by North American emergency physicians as well as patients intubated in the prehospital setting and emergency department (ED). This study assessed whether patients intubated in a UK prehospital setting or ED had excessive cuff pressures.

Paediatric sedation in emergency department: what is our practice?

Objectives: The aim of the present study was to document the use of sedation in paediatric patients in emergency departments within Australia and New Zealand.

Methods: A questionnaire was sent to 54 emergency departments throughout Australia and New Zealand.

Results: A total of 45 departments (83%) responded to the survey.