Uptake of core outcome sets in paediatric clinical trials: a protocol.

Introduction: A growing number of paediatric core outcome sets (COS) have been developed in the past 20 years. Previous studies have provided many useful insights into the uptake of COS. In addition to the awareness of COS among clinical trialists, the COS development process (especially patient participation) and the actions of the developers can promote COS uptake.

Children's processing of irony during reading in English: An eye-tracking study.

We know a great deal about the mechanisms underpinning literacy, yet gaps exist in understanding some complex literacy skills. The processing of irony during reading is one such skill. We used eye-tracking and behavioral measures to examine the processing of irony during reading in English in 30 children aged 10 to 12 years (33% female and 67% male; M = 11.

Carbon emissions associated with clinical trials: A scoping review.

Objectives: To review and synthesise available evidence on carbon emissions associated with clinical trials to inform future research on design and delivery of greener trials.

Study Design And Setting: We performed a scoping review by following the Joanna Briggs Institute (JBI) guidance and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). A systematic search was conducted on MEDLINE (Ovid) from 1 January 2007 to 15 April 2024 with no geographic and language restrictions complemented by forward and backward citation analysis (snowballing).

Comparative analysis of unicortical vs. subchondral locking screws in osteoporotic proximal humerus fractures.

Background: Proximal humerus fractures are common in adults aged 65 and older and provide challenges for osteoporotic patients due to the risk of suboptimal fixation and complications. Locking plates are often utilized to treat two-part fractures; however, ongoing concerns about their stability exist. This pilot study investigates the biomechanical impact of subchondral locking screws compared to unicortical screws in osteoporotic two-part cadaveric proximal humerus fractures.

The impact of patient choice on uptake, adherence, and outcomes across depression, anxiety, and eating disorders: a systematic review and meta-analysis.

Growing evidence highlights the critical role of patient choice of treatment, with significant benefits for outcomes found in some studies. While four meta-analyses have previously examined the association between treatment choice and outcomes in mental health, robust conclusions have been limited by the inclusion of studies with biased preference trial designs. The current systematic review included 30 studies across three common and frequently comorbid mental health disorders (depression  = 23; anxiety,  = 5; eating disorders,  = 2) including 7055 participants ( 42.