Publications by authors named "P A Tovo"
Article Synopsis
- Inflammatory bowel disease (IBD) encompasses Crohn's disease and ulcerative colitis, which are chronic immune-mediated conditions with unclear origins, hindering the development of new treatments.
- Human endogenous retroviruses (HERVs), making up 8% of the human genome, can influence inflammatory and autoimmune disorders when activated, and their expression is regulated by proteins TRIM28 and SETDB1 involved in immune response.
- A study using real-time PCR found that levels of HERV-H-pol and HERV-K-pol were significantly higher in IBD patients compared to healthy controls, while TRIM28 expression was decreased; these findings suggest that HERVs and TRIM28 may play key roles in IBD pathology,
Chronic immune thrombocytopenia (CITP) is an autoimmune disease whose underlying biologic mechanisms remain elusive. Human endogenous retroviruses (HERVs) derive from ancestral infections and constitute about 8% of our genome. A wealth of clinical and experimental studies highlights their pivotal pathogenetic role in autoimmune diseases.
View Article and Find Full Text PDFAccumulating evidence highlights the pathogenetic role of human endogenous retroviruses (HERVs) in eliciting and maintaining multiple sclerosis (MS). Epigenetic mechanisms, such as those regulated by TRIM 28 and SETDB1, are implicated in HERV activation and in neuroinflammatory disorders, including MS. Pregnancy markedly improves the course of MS, but no study explored the expressions of HERVs and of TRIM28 and SETDB1 during gestation.
View Article and Find Full Text PDFInterferons (IFNs) and IFN-stimulated genes (ISGs) play essential roles for the control of viral infections. Their expression in infants with respiratory syncytial virus (RSV) bronchiolitis is poorly defined. Human endogenous retroviruses (HERVs) represent 8% of our genome and modulate inflammatory and immune reactions.
View Article and Find Full Text PDFBackground: Intravenous administration of zidovudine (ZDV) during labour is a key step for vertical HIV transmission (VT) prevention, but there is no evidence of benefit when maternal HIV-RNA at delivery is <50 copies/mL. The aim of this study is evaluating the appropriateness of intrapartum ZDV use in Italy.
Methods: Observational study including mother-infant pairs with perinatal HIV exposure during 2002-2019, enrolled in the Italian Register for HIV Infection in Children.