Publications by authors named "P A Toro"
The concept of mental symptom is constructed considering not only the biological signal that determines it, but the multilayered causative factors related to intersubjective experience. However, specific brain damage might produce a set of symptoms expressed in a recognizable gestalt that helps to differentiate organic of psychogenic causation. The legacy of the theory of mental symptoms developed by German Berrios and the seminal work of Hughlings Jackson and Kurt Goldstein can contribute to this difficult task.
View Article and Find Full Text PDFAnal squamous cell carcinoma (SCC) incidence has increased, and treatment has shifted from surgery to chemoradiotherapy (CRT), with salvage abdominoperineal resection (APR) being reserved for persistent/recurrent cases. This study evaluates the utility of different Tumor Regression Scoring Systems (TRSS) in predicting survival in anal SCC patients, using pathologists' observations and digital pathology. Cases managed surgically from 2005 to 2019 were collected.
View Article and Find Full Text PDFDevelopment of novel organometallic sulfonamides with N-ethyl or N-methyl benzenesulfonamide units as potential human carbonic anhydrase I, II, IX and XII isoforms' inhibitors: Synthesis, biological evaluation and docking studies.
J Inorg Biochem
November 2024
Article Synopsis
- Researchers developed new cymantrenyl- and ferrocenyl-sulfonamide compounds as potential inhibitors for human carbonic anhydrases (hCAs) using aminobenzene sulfonamides and sulfonyl chlorides.
- These compounds were characterized through various techniques, including spectroscopic methods and single-crystal X-ray diffraction to determine their structures.
- Biological tests showed that compounds 1b and 2b effectively inhibited hCA II and IX isoforms, outperforming a standard drug, and docking studies indicated similar binding characteristics to established inhibitors.
Background: The density of tumour-infiltrating lymphocytes (TILs) could be prognostic in ductal carcinoma in situ (DCIS). However, manual TIL quantification is time-consuming and suffers from interobserver and intraobserver variability. In this study, we developed a TIL-based computational pathology biomarker and evaluated its association with the risk of recurrence and benefit of adjuvant treatment in a clinical trial cohort.
View Article and Find Full Text PDF(BRIDGE) is an innovative program designed to prevent homelessness and other negative outcomes among youth aging out of foster care. BRIDGE was pilot-tested on youth aging out of two orphanages in a city in southern Poland in 2009-2012. Youth were recruited at age 17, before aging out at age 18.
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