Publications by authors named "P A Sirois"
Article Synopsis
- Osteoarthritis is a major issue for athletic horses, causing pain and leading to early retirement, with hydro-expansive functionalized nanogels being explored as a potential treatment through a double-blinded randomized tolerance study.
- Eight healthy horses received injections of chitosan and hyaluronic acid nanogels and saline as controls, monitored for clinical signs and synovial fluid changes over three months.
- The study found mild synovitis in the treated group following injections, which resolved quickly, and while inflammation markers showed a temporary rise, there were no long-term adverse effects, indicating the treatment could be safe.
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues outside of the uterine cavity. Currently available drugs are efficacious in treating endometriosis-related pain, however it's not a targeted treatment. The aim of this work is to evaluate the effects of R-954, a bradykinin B1 receptor antagonist, in a murine model of endometriosis.
View Article and Find Full Text PDFThe case of the deepwater redfish (Sebastes mentella) in the Gulf of St. Lawrence (GSL) is a compelling example of drastic fluctuations in annual recruitment strength, characteristic of spasmodic stocks. After three decades of low abundance, the emergence of three consecutive strong year classes in 2011-2013 resulted in an unprecedented increase in biomass.
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- Heart failure due to heat stress is a significant concern for aquatic ectotherms, and mitochondrial dysfunction may play a key role in this issue.
- The study focused on the thermal sensitivity of cardiac mitochondria in three-spined stickleback fish, examining factors like temperature, fatty acid composition, and age.
- Results showed that while temperature strongly affected mitochondrial respiration, fish age also influenced it, revealing higher EPA levels in older fish but no direct correlation with critical thermal maximum (CTmax).
Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy.
J Clin Med
April 2023
Chagas disease, the parasitic infection caused by , afflicts about 6 million people in Latin America. Here, we investigated the hypothesis that may fuel heart parasitism by activating B1R, a G protein-coupled (brady) kinin receptor whose expression is upregulated in inflamed tissues. Studies in WT and B1R mice showed that DNA levels (15 days post infection-dpi) were sharply reduced in the transgenic heart.
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