Publications by authors named "P A Sidoti"
Article Synopsis
- The study aimed to evaluate how different artificial tears (AT) affect the thickness of tear film sublayers using a new imaging device.
- Results showed that all tested ATs significantly increased the mucoaqueous layer thickness (MALT) at 1 minute post-instillation, with the Systane Complete PF (SYS) formulation providing the most substantial increase.
- The findings suggest that while all ATs work quickly to enhance tear film thickness, the effectiveness and duration of these effects vary, indicating the need for personalized AT selection for patients.
Using Multi-Layer Perceptron Driven Diagnosis to Compare Biomarkers for Primary Open Angle Glaucoma.
Invest Ophthalmol Vis Sci
September 2024
Purpose: To use neural network machine learning (ML) models to identify the most relevant ocular biomarkers for the diagnosis of primary open-angle glaucoma (POAG).
Methods: Neural network models, also known as multi-layer perceptrons (MLPs), were trained on a prospectively collected observational dataset comprised of 93 glaucoma patients confirmed by a glaucoma specialist and 113 control subjects. The base model used only intraocular pressure, blood pressure, heart rate, and visual field (VF) parameters to diagnose glaucoma.
: To investigate macular vascular biomarkers for the detection of primary open-angle glaucoma (POAG). : A total of 56 POAG patients and 94 non-glaucomatous controls underwent optical coherence tomography angiography (OCTA) assessment of macular vessel density (VD) in the superficial (SCP), and deep (DCP) capillary plexus, foveal avascular zone (FAZ) area, perimeter, VD, choriocapillaris and outer retina flow area. POAG patients were classified for severity based on the Glaucoma Staging System 2 of Brusini.
View Article and Find Full Text PDFPurpose: The purpose of this study was to investigate the effects of artificial tears (AT) on the sublayers of the tear film assessed by a novel tear film imaging (TFI) device.
Methods: The mucoaqueous layer thickness (MALT) and lipid layer thickness (LLT) of 198 images from 11 healthy participants, 9 of whom had meibomian gland disease, were prospectively measured before and after exposure to 3 different AT preparations (Refresh Plus; Retaine [RTA]; Systane Complete PF [SYS]), using a novel nanometer resolution TFI device (AdOM, Israel). Participants were assessed at baseline and at 1, 5, 10, 30, and 60 minutes after instilling 1 drop of AT during 3 sessions on separate days.