[Quality of life of patients with multiple sclerosis in the Smolensk region].

Objective: To study the quality of life (QoL) of patients with multiple sclerosis (MS) in the Smolensk region who receive MS disease-modifying therapies (DMT).

Material And Methods: The study included 37 patients receiving MS DMT. The 36-Item Short Form Health Survey (SF-36), the Multiple sclerosis Quality of Life (MusiQol), the Hamilton Depression Rating Scale, a scale of satisfaction with treatment, the Fatigue Severity Scale were administered.

Resonant electron capture by polycyclic aromatic hydrocarbon molecules: Effects of aza-substitution.

Resonant electron capture by aza and diaza derivatives of phenanthrene (7,8-benzoquinoline and 1,10-phenanthroline) and anthracene (acridine and phenazine) at incident free electron energies (Ee) in the range of 0-15 eV was studied. All compounds except 7,8-benzoquinoline form long-lived molecular ions (M-) at thermal electron energies (Ee ∼ 0 eV). Acridine and phenazine also form such ions at epithermal electron energies up to Ee = 1.

Resonant electron capture by 5-Br-2'-deoxyuridine.

The results of the study of resonant electron capture by molecules of 5-Br-2'-deoxyuridine (BrdUrd) over the range of electron energies from near zero to 14 eV are described. In the thermal energy range, long-lived molecular negative ions, unstable with respect to autoneutralization and dehalogenation, have been registered. Examination of the kinetics of these decay processes led us to the conclusion that the most probable structure for molecular negative ions is that with an extended C-Br bond, which was predicted earlier using quantum-chemical calculations.

A unified statistical RRKM approach to the fragmentation and autoneutralization of metastable molecular negative ions of hexaazatrinaphthylenes.

For the compounds promising for use as n-type semiconductors in organic electronics and energy storage devices, hexaazatrinaphthylene (HATNA) and its derivative hexamethoxy-hexaazatrinaphthylene (HMHATA), the monomolecular processes occurring under the exposure of molecules to low-energy (0-15 eV) free electrons were studied by means of resonant electron capture negative ion mass spectrometry. Resonant electron attachment results in the formation of eminently long-lived molecular negative ions (MNIs) in an abnormally wide range of incident electron energy (E) from 0 to 5-7 eV. For both compounds, this observation serves as an indication of the strong electron-accepting properties and high stability of MNIs against electron autodetachment.

Resonant electron capture by uridine and deoxyuridine molecules: Fragmentation with charge transfer.

Rationale: Charge transfer via DNA plays an important role in physical and chemical processes in biological systems, and is used in biomolecular electronics. The present study considers the resonant interaction of free electrons with nucleosides, which is important for an understanding of the processes of electron transport in DNA.

Methods: Resonant electron capture negative ion mass spectrometry was used to study the processes of low-energy electron attachment to two uracil nucleosides, uridine and deoxyuridine, while density functional theory (DFT) calculations were used to analyze the energy aspects of ion formation and decay.