Publications by authors named "P A Seligman"
Article Synopsis
- - The study found that the Na-K-ATPase signaling pathway contributes to anemia in a kidney disease model (5/6th partial nephrectomy), and this anemia is marked by reduced red blood cell (RBC) survival but no significant changes in iron levels.
- - Administration of the peptide pNaKtide, which blocks the harmful signaling loop, improved RBC survival and normalized hematocrit levels, while other forms of the peptide did not have the same effects.
- - These findings suggest that targeting the Na-K-ATPase signaling could offer new treatment options for anemia in chronic kidney disease patients, beyond the current reliance on erythropoietin-based therapies.
Laminin coated diamond electrodes for neural stimulation.
Mater Sci Eng C Mater Biol Appl
January 2021
The performance of many implantable neural stimulation devices is degraded due to the loss of neurons around the electrodes by the body's natural biological responses to a foreign material. Coating of electrodes with biomolecules such as extracellular matrix proteins is one potential route to suppress the adverse responses that lead to loss of implant functionality. Concurrently, however, the electrochemical performance of the stimulating electrode must remain optimal to continue to safely provide sufficient charge for neural stimulation.
View Article and Find Full Text PDFObjective: With the strong drive towards miniaturization of active implantable medical devices and the need to improve the resolution of neural stimulation arrays, there is keen interest in the manufacture of small electrodes capable of safe, continuous stimulation. Traditional materials such as platinum do not possess the necessary electrochemical properties to stimulate neurons safely when electrodes are very small (i.e.
View Article and Find Full Text PDFIron metabolism is altered in a variety of cancers; however, little is known about the role of iron metabolism in the biology and response to therapy of acute myeloid leukemia (AML). Here we show that SLC40A1, the gene encoding the iron exporter ferroportin (FPN), is variably expressed among primary AMLs and that low levels are associated with good prognosis and improved outcomes. In particular, core binding factor (CBF) AMLs, which are associated with good outcomes with chemotherapy, consistently have low level of SLC40A1 expression.
View Article and Find Full Text PDFBackground: In September 2016, the Food and Drug Administration (FDA) published a draft guidance for industry, , that detailed the factors the Agency considers in determining when a Risk Evaluation and Mitigation Strategy (REMS) is necessary. The objective of this study was to determine how the FDA has applied these criteria for newly approved drugs.
Methods: For the 3-year period, 2015-2017, which included a full year of FDA approvals both before and after the issuance of the draft guidance, publicly available FDA reviews were analyzed for all 113 approved products using the criteria outlined in the guidance.