Higher Risk Renal Angiomyolipomas: Surveillance Remains a Safe Management Option.

Purpose: This retrospective study furthers our understanding of risk factors associated with hemorrhage and intervention in renal angiomyolipomas (R-AMLs), particularly in larger tumors (≥ 4 cm) and in childbearing-age (CBA; younger than 50 years) women. The objective was to refine risk stratification and optimize patient management.

Methods: Review of our institutional database identified patients with radiographic R-AML from 1997 to 2023.

Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release.

Background/objectives: This study investigates for the first time the use of the prilling technique in combination with solvent evaporation to produce nano- and submicrometric PLGA particles to deliver properly an active pharmaceutical ingredient. Curcumin (CCM), a hydrophobic compound classified under BCS (Biopharmaceutics Classification System) class IV, was selected as the model drug.

Methods: Key process parameters, including polymer concentration, solvent type, nozzle size, and surfactant levels, were optimized to obtain stable particles with a narrow size distribution determined by DLS analysis.

Integrating Analytical Procedures in Routine Practices of Centralized Antiblastic Compounding Units for Valorization of Residual Compounded Drugs.

Background/objectives: Although extemporaneous formulations of anticancer drug products for personalized therapy are produced according to Good Hospital Pharmacy Manufacturing Practice, the lack of knowledge about drug stability under clinical conditions limits the second-time use of these highly costly medications in clinical practice. Therefore, the residual compounded drugs are considered waste and a cost item that negatively affects the healthcare system. In the context of the ever-increasing interest of the health system in applying practices in line with personalized medicine and spending review policies, this research aimed to demonstrate the feasibility of incorporating analytical techniques into daily routine practice.

Advanced flame-retardant biocomposites: Polylactic acid reinforced with green gallic acid‑iron‑phosphorus coated flax fibers.

This study introduces a sustainable approach for enhancing the fire retardancy and smoke suppression of poly(lactic acid) (PLA) composites, contributing to addressing one of the major challenges in biocomposites that limits their application in various engineering fields, as automotive and construction sectors. Flax fibers (FF) were surface functionalized with a novel organic-inorganic hybrid flame retardant (FR), offering a sustainable bioinspired approach that mitigates potential mechanical properties impairment and FR leaching, which can cause environmental concerns and reduced composite durability. The process involves a three-step coating procedure.