Central activation, metabolites, and calcium handling during fatigue with repeated maximal isometric contractions in human muscle.

Purpose: To determine the roles of calcium (Ca) handling by sarcoplasmic reticulum (SR) and central activation impairment (i.e., central fatigue) during fatigue with repeated maximal voluntary isometric contractions (MVC) in human muscles.

Moderate- and high-intensity exhaustive exercise in the heat induce a similar increase in monocyte Hsp72.

This study examined the relationship between exhaustive exercise in the heat at moderate and high intensities on the intracellular heat shock protein 72 (iHsp72) response. Twelve male subjects cycled to exhaustion at 60 and 75% of maximal oxygen uptake in hot conditions (40 °C, 50% RH). iHsp72 concentration was measured in monocytes before, at exhaustion and 24 h after exercise.

Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats.

Erythropoietin (EPO) ameliorates glucose metabolism through mechanisms not fully understood. In this study, we investigated the effect of EPO on glucose metabolism and insulin signaling in skeletal muscle. A 2-week EPO treatment of rats fed with a high-fat diet (HFD) improved fasting glucose levels and glucose tolerance, without altering total body weight or retroperitoneal fat mass.

The effect of ice-slushy consumption on plasma vasoactive intestinal peptide during prolonged exercise in the heat.

The aim of this study was to determine the effect of exercise in the heat on thermoregulatory responses and plasma vasoactive intestinal peptide concentration (VIP) and whether it is modulated by ice-slushy consumption. Ten male participants cycled at 62% V̇O2max for 90min in 32°C and 40% relative humidity. A thermoneutral (37°C) or ice-slushy (-1°C) sports drink was given at 3.

Combined caffeine and carbohydrate ingestion: effects on nocturnal sleep and exercise performance in athletes.

Purpose: In athletes, caffeine use is common although its effects on sleep have not been widely studied. This randomised, double-blind, placebo-controlled crossover trial investigated the effects of late-afternoon caffeine and carbohydrate-electrolyte (CEB) co-ingestion on cycling performance and nocturnal sleep.

Methods: Six male cyclists/triathletes (age 27.