Publications by authors named "P A Riccio"

Vitamin D deficiency and insufficiency are becoming a common global issue for us, especially in the most industrially developed countries. The only acknowledged activity of vitamin D in vertebrates is to promote the absorption of calcium and, therefore, allow for the mineralization of bones. Accordingly, its deficiency is associated with diseases such as rickets.

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Article Synopsis
  • Cellular movement is crucial for key biological processes, influencing both single-cell activities like division and the collective behavior of cells in tissues for proper development.
  • This movement also plays a significant role in diseases, particularly in cancer metastasis, highlighting its importance in understanding pathology.
  • The text discusses various experimental methods and analytical tools designed to study and quantify the nuances of cell migration, covering both traditional and modern computational techniques.
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Air contamination in operating rooms (ORs) depends on the conditions of the room and on activities therein performed. Methodologies of air quality assessment in ORs are often inadequately described in the scientific literature, and the time required for a change in status in air quality is never taken into account. The purpose of this study was to determine the influence of the state and the presence of human operators on air quality by implementing a precise measurement protocol that also took into account the time required for changes in the room to affect air pollution.

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Ferroptosis is a recently recognized form of regulated cell death involving lipid peroxidation. Glutathione peroxidase 4 (GPX4) plays a central role in the regulation of ferroptosis through the suppression of lipid peroxidation generation. Connections have been reported between ferroptosis, lipid metabolism, cancer onset, and drug resistance.

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Article Synopsis
  • Cancer metastasis makes treatment less effective, highlighting the need for reliable markers to detect its onset.
  • The 65 kDa isoform of MMP-9 is suggested as a better biomarker than the more commonly referenced 82 kDa form, as it becomes more active during the progression of diseases like lung and breast cancer.
  • Targeting the enzymes that convert the 82 kDa MMP-9 into the active 65 kDa form might lead to new treatments that can effectively prevent metastasis.
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