Publications by authors named "P A Ouellet"
Article Synopsis
- The study investigated the occurrence and risk factors of adverse events (AEs) related to intravenous immunoglobulin (IVIG) therapy in hospitalized children under 18 years old.
- A total of 228 patients were reviewed, resulting in 478 IVIG treatments, with mild reactions like fever and headache being the most common, although some reactions were severe.
- Key predictors of IVIG-AEs included older age, dehydration, allergies, being on the first treatment, and receiving higher doses, while concurrent steroid use seemed to reduce risk.
Background: Umbilical artery gas results help obstetricians assess fetal well-being during labor and guide screening decisions on eligibility for therapeutic hypothermia (ie, whole-body or head cooling). The accuracy of results, especially for the base deficit on arterial cord gas analysis, in predicting brain injury is questioned. A novel biomarker specifically calculated for fetal acid-base physiology and response to asphyxia-neonatal eucapnic pH as a marker of neonatal metabolic acidosis-has the potential to be an accurate predictor of hypoxic-ischemic encephalopathy.
View Article and Find Full Text PDFIs it time to end the use of base deficit for fetal well-being assessment?
Am J Obstet Gynecol
September 2024
Article Synopsis
- Authors are concerned about using base deficit measurements from umbilical artery blood samples to evaluate fetal well-being during labor and predict neonatal health issues.
- Both whole blood and extracellular fluid classifications of base deficit rely on normal adult acid-base characteristics, ignoring the specific in utero conditions that exist during fetal development.
- Misinterpretation of these measurements can lead to inaccurate assessments, potentially affecting clinical decisions related to fetal heart rate monitoring and neonatal outcomes.
Objective: To consider the classical use of "pH < 7.0 and/or a base deficiency ≥12 mmol/L" as markers of the risk of neonatal hypoxic-ischemic encephalopathy (HIE), recalling various criticisms of the use of these markers in favor of that of neonatal eucapnic pH, which appears to be a better marker of this risk.
Methods: Fifty-five cases of acidemia with pH < 7.
Background: Cardiopulmonary resuscitation (CPR) decreases lung volume below the functional residual capacity and can generate intrathoracic airway closure. Conversely, large insufflations can induce thoracic distension and jeopardize circulation. The capnogram (CO signal) obtained during continuous chest compressions can reflect intrathoracic airway closure, and we hypothesized here that it can also indicate thoracic distension.
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