Publications by authors named "P A Melnikov"
Poly(lactide-co-glycolide) (PLG) nanoparticles loaded with doxorubicin have reached phase-I clinical trials for treating advanced solid tumors. This study explores cell hitchhiking, where nanoparticles associate with blood cells and investigates the impact on pharmacokinetics and tumor migration. Previous findings highlighted the early post-injection phase dominated by nonspecific nanoparticle-cell interactions and burst release.
View Article and Find Full Text PDFPurpose: This study investigated the brain targeting mechanism of doxorubicin-loaded polybutyl cyanoacrylate (PBCA) nanoparticles, particularly their interactions with the blood-brain barrier (BBB). The BBB protects the brain from drugs in the bloodstream and represents a crucial obstacle in the treatment of brain cancer.
Methods: An advanced computer model analyzed the brain delivery of two distinct formulations, Doxil and surfactant-coated PBCA nanoparticles.
Lactide is one of the most popular and promising monomers for the synthesis of biocompatible and biodegradable polylactide and its copolymers. The goal of this work was to carry out a full cycle of polylactide production from lactic acid. Process conditions and ratios of reagents were optimized, and the key properties of the synthesized polymers were investigated.
View Article and Find Full Text PDFThe use of biocidal agents is a common practice for protection against biofouling in biomass-rich environments. In this paper, oligohexamethyleneguanidine (OHMG) polymer, known for its biocidal properties, was further modified with para-aminosalicylic acid (PAS) to enhance its properties against microorganisms coated with a lipid membrane. The structure of the product was confirmed by H NMR, C NMR, and FTIR spectroscopy.
View Article and Find Full Text PDFArticle Synopsis
- PLG nanoparticles are promising for cancer therapy due to their effectiveness and biodegradability, making it crucial to study their interactions with blood cells and how they distribute in the body.
- Three types of doxorubicin-loaded PLG nanoparticles were created and analyzed for their characteristics and drug release behaviors, with real-time tracking of their movement in tumor-bearing mice.
- The study found that after injection, PLG nanoparticles quickly released the drug and interacted with blood cells, affecting how the drugs are processed and cleared from circulation, providing insights for improving nanoparticle drug delivery in cancer treatment.